[PubMed] [Google Scholar]Yin T, Green KJ (2004). were not discovered in sera from regular handles (n: 19) or sufferers with various other autoimmune illnesses, including bullous pemphigoid (n:20), epidermolysis bullosa acquisita (n:2), lupus (n:3), and Sezary symptoms (n:1). The current presence of anti-E-cadherin reactivity in sera of sufferers with PF, FS, and mcPV was confirmed by Maackiain ELISA. Immnuofluorescence staining of A431 cells Maackiain by PF/FS sera signifies that anti-E-cadherin antibodies also bind indigenous E-cadherin. This scholarly research supplies the initial proof that PF, FS, and mcPV sufferers have got circulating autoantibodies against E-cadherin, a traditional cadherin situated in adherens junctions between epithelial cells. 126: 29 (abstract) Personal references Amagai M, Klaus-Kovtun V, Stanley JR (1991). Autoantibodies against a book epithelial cadherin in pemphigus vulgaris, an illness of cell adhesion. Cell 67: 869C877. [PubMed] [Google Scholar]Amagai M, Tsunoda K, Zillikens D, Nagai T, Nishikawa T (1999). The scientific phenotype of pemphigus is normally defined with the anti-desmoglein autoantibody profile. J Am Acad Dermatol 40: 67C70. [PubMed] [Google Scholar]Amagai M, Karpati S, Prussick R, Klaus-Koytun V, Stanley JR (1992). Autoantibodies against the amino-terminal cadherin-like binding domains of pemphigus vulgaris antigen are pathogenic. J Clin Invest 90: 919C926. [PMC free of charge content] [PubMed] [Google Scholar]Amagai M, Hashimoto T, Green KJ, Shimizu N, Nishikawa T (1995). Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus. J Invest Dermatol 104: 895C901. [PubMed] [Google Scholar]Anhalt GJ, Labib RS, Voorhees JJ, Beals TF, Diaz LA (1982). Induction of pemphigus in neonatal mice by unaggressive transfer of IgG from sufferers with the condition. N Engl J Med 306: 1189C1196. [PubMed] [Google Scholar]Arteaga LA, Prisayanh PS, Warren SJP, Liu Z, Diaz LA, Lin MS (2002). A subset of Pemphigus Foliaceus Sufferers Exhbits Pathogenic Autoantibodies against Desmoglein-3 and Desmoglein-1. J Invest Dermatol Maackiain 118: 806C811. [PubMed] [Google Scholar]Aoyama Y, Owada MK, Kitajima Y (1999). A pathogenic autoantibody, pemphigus vulgaris-IgG, induces phosphorylation of desmoglein 3, and its own dissociation from plakoglobin in cultured keratinocytes. Eur J Immunol 29:2233C2240. [PubMed] [Google Scholar]Berkowitz P, Hu P, Liu Z, Diaz LA, Enghild JJ, Chua MP et al. (2005). Desmosome Signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization. J Biol Chem 280: 23778C23784. [PubMed] [Google Scholar]Calkins CC, Setzer SV, Jennings JM, Summers S, Tsunoda K, Amagai M et al. (2006). Desmoglein endocytosis and desmosome disassembly are coordinated replies to pemphigus autoantibodies. J Bol CACNLB3 Chem 281: 7623C7634. [PubMed] [Google Scholar]Diaz LA, Arteaga LA, Hilario-Vargas J, Valenzuela JG, Li N, Warren S et al. (2004). Anti-desmoglein-1 antibodies in onchocerciasis, chagas and leishmaniasis Disease suggest a possible etiological connect to Fogo Selvagem. J Invest Dermatol 123:1045C1051. [PubMed] [Google Scholar]Diaz LA, Sampaio SAP, Rivitti EA, Martins CR, Cunha PR, Lombardi C et al. (1989). Endemic pemphigus foliaceus (fogo selvagem): II. Historical and Current epidemiologic research. J Invest Dermatol 92: 4C12. [PubMed] [Google Scholar]Ding X, Aoki V, Mascaro JM Jr, Lopez-Swiderski A, Diaz LA, Fairley JA (1997). Mucosal and mucocutaneous (generalized) pemphigus vulgaris present distinctive autoantibody profiles. J Invest Dermatol 109: 592C596. [PubMed] [Google Scholar]Ding X, Diaz LA, Fairley JA, Giudice GJ, Liu Z (1999). The anti-desmoglein 1 autoantibodies in pemphigus vulgaris sera are pathogenic. J Invest Dermatol 112: 739C743. [PubMed] [Google Scholar]Eyre RW, Stanley JR (1987). Individual autoantibodies against a desmosomal proteins complex using a calcium-sensitive epitope are quality of pemphigus foliaceus sufferers. J Exp Med 165: 1719C1724. [PMC free of charge content] [PubMed] [Google Scholar]Fiebiger E, Hammerschmid F, Stingl G, and Maurer D (1998). Anti-FcepsilonRIalpha autoantibodies in autoimmune-mediated disorders. Id of the structureCfunction romantic relationship. J Clin Invest 101: 243C251. [PMC free of charge content] [PubMed] [Google Scholar]Fouquet S, Lugo-Martinez VH, Faussat AM, Renaud F, Cardot P, Chambaz (2004). Early lack of E-cadherin from cell-cell connections is mixed up in onset of Anoikis in enterocytes. J Biol Chem 279: 43061C43069. [PubMed] [Google Scholar]Furukawa F, Takigawa M, Matsuyoshi N, Shirahama S, Wakita H, Fujita M et al. (1994). Cadherins in cutaneous biology. J Maackiain Dermatol 21: 802C813. [PubMed] Maackiain [Google Scholar]Futamura S, Martins C,.
