The info obtained in the current study suggest that GPIIbIIIa may be also involved in positive and negative modulation of platelet apoptosis triggered by thrombin- and calcium ionophore-mediated pathways, when apoptosis is potentiated by sending pro-apoptotic signals through active GPIIbIIIa, and inhibited by binding of the fibrinogen-mimetic therapeutics, Integrilin and Aggrastat
The info obtained in the current study suggest that GPIIbIIIaRead More